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Genetics 466 Course Outline - Fall 2008
2:25 MWF 132 Noland Hall
Prof. Sean Carroll
Prof. John Doebley
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| Date |
Lecture Topic |
Readings |
Suggested Problems |
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| Part 1. |
Genes, Chromosomes and Linkage |
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| Sept 3 |
1. Mendel and The Study of Inheritance |
1:1-28; 2:31-42 |
2:22, 26, 30, 33, 35, 36, 55, 58 |
Daily |
Lecture |
| Sept 5 |
2. Cell Cycle, Mitosis and Meiosis |
2:42-61 |
2:4, 8, 9, 13, 14, 17 |
Daily |
Lecture |
| Sept 8 |
3. Probability for Genetic Events |
3:89-97, Handout D1 |
3:1-3, 14, 17-20, 37 |
Daily |
Lecture |
| Sept 10 |
4. Probability for Repeated Trials |
Handout D2 |
3:35b |
Daily |
Lecture |
| Sept 12 |
5. Testing Genetic Hypotheses |
3:97-99, Handout D3 |
3:13, 25, 26 |
Daily |
Lecture |
| Sept 15 |
6. Extensions to Mendelism |
6:221-249 |
6:2, 5-14, 21, 33, 44, 51, 53 |
Daily |
Lecture |
| Sept 17 |
7. Chromosomes, Sex and Mendel |
2:61-75 |
2:29, 37-38, 42-43, 46-48, 50, 52 |
Daily |
Lecture |
| Sept 19 |
8. Chromosome Number |
16:555-572 |
16:2, 4, 10, 34-35, 37, 39, 51 |
Daily |
Lecture |
| Sept 22 |
9. Chromosome Rearrangements |
16:572-586 |
16:15, 19, 23, 24, 28 |
Daily |
Lecture |
| Sept 24 |
10. Linkage and Mapping I |
4:129-144, 155-157, 159-162, Handout D4 |
4:1-4, 7, 9-10, 12-13, 27, 37, 44, 53 |
Daily |
Lecture |
| Sept 26 |
11. Linkage and Mapping II |
4:154-155, 162-163 |
4:25-26, 28a, 33-34, 38 |
Daily |
Lecture |
| Sept 29 |
12. Linkage and Mapping III |
4:158-159, Handout D5 |
4:23, 43 |
Daily |
Lecture |
| Oct 1 |
13. Model Organisms |
1:17-21, 759-773 |
- |
Daily |
Lecture |
| Oct 2 |
Exam I Thursday Evening 7:15 till 9:15 - Rms B102 & B239 Van Vleck (Lectures 1 to 13) |
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(Practice Exam) |
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|
| Part 2. |
Molecular Biology of the Gene |
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|
|
| Oct 3 |
14. Central Dogma I: DNA |
7:265-275 |
7:1-4, 11, 16; SP 1-2 |
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| Oct. 6 |
15. Central Dogma II: Replication |
7:275-291 |
7:5-8, 19, 21, 23-24 |
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| Oct. 8 |
16. Central Dogma III: RNA transcription |
8:295-308 |
8:1-2, 7, 12, 14,18 |
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| Oct 10 |
17. Translation and Genetic Code I |
9:320-333 |
9:1-3, 6, 9; SP 1-2 |
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| Oct. 13 |
18. Translation and Genetic Code II |
9:333-344 |
9:5, 17, 24, 27, 28, 32 |
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| Oct. 15 |
19. Gene Expression I: lac operon |
10:351-363 |
10:1-2, 4, 6; SP 1-2 |
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| Oct. 17 |
20. Gene Expression II: operators and repressors |
10:363-371 |
10:5, 9, 13, 15 |
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| Oct. 20 |
21. Gene Expression III: Phage and gene batteries |
10:372-379 |
10:7-8, 16-18 |
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| Oct. 22 |
22. Eukaryotic gene regulation I |
11:385-394 |
11:1-3 |
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|
| Oct. 24 |
23. Eukaryotic gene regulation II |
11:394-401, 404-406 |
11:4-8, 10, 15, 17 |
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| Oct. 27 |
24. Animal Development I: The toolkit |
12:415-423 |
- |
|
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| Oct. 29 |
25. Animal Development II: The homeobox |
12:423-432 |
12:1-3, 7-9 |
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| Oct 31 |
26. Animal Development III: Building Animals |
12:432-439 |
12:4, 6, 10-13 |
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| Nov 3 |
27. Animal Development IV: Building Animals |
12:439-449 |
12:14-16 |
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| Part 3. |
Evolutionary Genetics |
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|
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| Nov 4 |
Exam II Tuesday Evening 7:15 till 9:15 - Rm 125 Ag Hall (Lectures 14 to 26) |
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| Nov 5 |
28. Reverend Darwin's Detour |
Into the Jungle: Chapter 1 |
TBA |
|
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| Nov 7 |
29. Genomics and the new Genetics |
13:453-468 |
13:1-2, 6, 11, 13, 15 |
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| Nov 10 |
30. Comparative Genomics and Reverse Genetics |
13:468-483 |
13:16-18, 22, 24 |
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| Nov 12 |
31. Evolution of Gene Function I: Sickle Cell Safari |
Into the Jungle: Chapter 8 |
TBA |
|
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| Nov 14 |
32. Evolution of Gene Function II: In Cold Blood |
Into the Jungle: Chapter 9 |
TBA |
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|
| Nov 17 |
33. Morphological Evolution |
19:694-699, TBA |
TBA |
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| Nov 19 |
34. Endless Forms Most Beautiful |
TBA |
TBA |
|
|
| Nov 21 |
35. Hardy-Weinberg & The Gene Pool Concept |
17:603-618 |
17:2-3, 10a, 12 |
Daily |
Lecture |
| Nov 24 |
36. Inbreeding |
17:618-622 |
17:16, 20 |
Daily |
Lecture |
| Nov 26 |
37. Genetic Drift |
17:631-633, 19:690-693 |
- |
Daily |
Lecture |
| Dec 1 |
38. Modeling Natural Selection |
17:623-631 |
17:5-6, 11 |
Daily |
Lecture |
| Dec 3 |
39. The Inheritance of Complex Traits |
18:639-646, 664-671, Handout D6 |
18:2, 6-7 (data file) |
Daily |
Lecture |
| Dec 5 |
40. Nature versus Nurture |
18:651-659, 671-673, Handout D7 |
- |
Daily |
Lecture |
| Dec 8 |
41. Genetics of Plant and Animal Breeding |
18:659-664, Handout D8 |
18:5, 14 |
Daily |
Lecture |
| Dec 9 |
Exam III Tuesday Evening 7:15 till 9:15 - Rm 125 Ag Hall (Lectures 27 to 41) |
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(Practice Exam) |
KEY |
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| Dec 10 |
42. Genetics and domestication |
- |
- |
Daily |
Lecture |
| Dec 12 |
43. Overview |
- |
- |
- |
- |
| Dec 16 |
Final Exam Tuesday Afternoon 2:45 till 4:45 - Rm 6210 Social Science (covers the whole course) |
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KEY |
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Instructors |
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Email |
Office |
Office Hour |
Voice |
| Sean Carroll |
sbcarrol@wisc.edu |
201A Bock Labs |
by appointment |
262-6191 |
| John Doebley |
jdoebley@wisc.edu |
5320 Genetics/Biotechnology |
by appointment |
265-5803 |
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