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Genetics 466 Course Outline - Fall 2010
1:20 MWF 125 Ag Hall
Prof. John Doebley
Prof. Allen Laughon
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| Date |
Lecture Topic |
Readings |
Suggested Problems |
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| Part 1. |
Genes, Chromosomes and Linkage |
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| Sept 3 |
1. Mendel and The Study of Inheritance |
1:1-28; 2:31-42 |
2:22, 26, 30, 33, 35, 36, 55, 58 |
Daily |
Lecture |
| Sept 8 |
2. Cell Cycle, Mitosis and Meiosis |
2:42-61 |
2:4, 8, 9, 13, 14, 17 |
Daily |
Lecture |
| Sept 10 |
3. Probability for Genetic Events |
3:89-97, Handout D1 |
3:1-3, 14, 17-20, 37 |
Daily |
Lecture |
| Sept 13 |
4. Probability for Repeated Trials |
Handout D2 |
3:35b |
Daily |
Lecture |
| Sept 15 |
5. Testing Genetic Hypotheses |
3:97-99, Handout D3 |
3:13, 25, 26 |
Daily |
Lecture |
| Sept 17 |
6. Extensions to Mendelism |
6:221-249 |
6:2, 5-14, 21, 33, 44, 51, 53 |
Daily |
Lecture |
| Sept 20 |
7. Chromosomes, Sex and Mendel |
2:61-75 |
2:29, 37-38, 42-43, 46-48, 50, 52 |
Daily |
Lecture |
| Sept 22 |
8. Chromosome Number |
16:555-572 |
16:2, 4, 10, 34-35, 37, 39, 51 |
Daily |
Lecture |
| Sept 24 |
9. Chromosome Rearrangements |
16:572-586 |
16:15, 19, 23, 24, 28 |
Daily |
Lecture |
| Sept 27 |
10. Linkage and Mapping I |
4:129-144, 155-157, 159-162, Handout D4 |
4:1-4, 7, 9-10, 12-13, 27, 37, 44, 53 |
Daily |
Lecture |
| Sept 29 |
11. Linkage and Mapping II |
4:154-155, 162-163, Handout D5 |
4:25-26, 28a, 33-34, 38 |
Daily |
Lecture |
| Oct 1 |
12. Linkage and Mapping III |
4:158-159, Handout D6 |
4:23, 43 |
Daily |
Lecture |
| Oct 4 |
13. Model Organisms |
1:17-21, 759-773 |
- |
Daily |
Lecture |
| Part 2. |
Molecular Biology of the Gene |
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| Oct 6 |
14. DNA structure and chromosome packaging |
7:265-275 |
7:14, 16, 24, 25, 28 |
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| Oct 7 |
Exam I Thursday Evening 7:15 till 9:15 - Room 125 Ag Hall (Lectures 1 to 13) |
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Practice Exam, Exam 2008 |
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| Oct 8 | 15. DNA replication I | 7: 275-281 | 7:14,15,18,19,21,22,24 | | |
| Oct 11 | 16. DNA replication II | 7: 281-291 | 7:15 | | |
| Oct 13 | 17. Recombinant DNA I | 20:715-730 | 20:13,17 | | |
| Oct 15 | 18. Recombinant DNA II | 20:731-740 | 20:18,21 | | |
| Oct 18 | 19. Transcription I | 8:295-307 | 8:5,7,10,17 | | |
| Oct 20 | 20. Transcription II | 8:307-315 | 8:11,18,20 | | |
| Oct 22 | 21. Translation & genetic code I | 9:319-323, 330-339 | 9:2,9 | | |
| Oct 25 | 22. Translation & genetic code II | 9:324-330, 332, 339-344 | 9:1,2,19,27,28,30,32,33 | | |
| Oct 27 | 23. Mutation | 15:513-531, | 15:3-5,26-30 | | |
| Oct 29 | 24. DNA repair & recombination | 15:531-550 | 15:12,17,34,35 | | |
| Nov 1 | 25. Bacterial genetics I | 5:181-195 | 5:8,10,13,14,19,22,26,27,29 | | |
| Nov 3 | 26. Bacterial genetics II | 5:195-213 | 5:16,17,19-21,24,31,32 | | |
| Nov 5 | 27. Prokaryotic gene regulation | 10:351-371 | 10:3,4,15,18 | | |
| Nov 8 | 28. Eukaryotic gene regulation I | 11:385-401 | 11:3,23-24 | | |
| Nov 9 |
Exam II Tuesday Evening 7:15 till 9:15 - Room 125 Ag Hall (Lectures 14 to 27) |
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| Nov 10 | 29. Eukaryotic gene regulation II | 11:439-445 | 12:15,16 |
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| Nov 12 | 30. Regulation by noncoding RNA | 8:312-314, | TBA |
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| Nov 15 | 31. Epigenetics I | 11:402-411 | 11:11-13,20-22 | | |
| Nov 17 | 32. Epigenetics II | 11:402-411 |
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| Nov 19 | 33. Transposable elements I | 14:487-496 | 14:9-11 | | |
| Nov 22 | 34. Transposable elements II | 14:496-510 | 14:2,8,12 | | |
| Part 3. |
Population and Evolutionary Genetics |
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| Nov 24 |
35. Hardy-Weinberg & The Gene Pool Concept |
17:603-618 |
17:2-3, 10a, 12 |
Daily |
Lecture |
| Nov 29 |
36. Inbreeding |
17:618-622 |
17:16, 20 |
Daily |
Lecture |
| Dec 1 |
37. Genetic Drift |
17:631-633, 19:690-693 |
- |
Daily |
Lecture |
| Dec 3 |
38. Modeling Natural Selection |
17:623-631 |
17:5-6, 11 |
Daily |
Lecture |
| Dec 6 |
39. The Inheritance of Complex Traits |
18:639-646, 664-671, Handout D7 |
18:2, 6-7 (data file) |
Daily |
Lecture |
| Dec 8 |
40. Nature versus Nurture |
18:651-659, 671-673, Handout D8 |
- |
Daily |
Lecture |
| Dec 10 |
41. Genetics of Plant and Animal Breeding |
18:659-664, Handout D9 |
18:5, 14 |
Daily |
Lecture |
| Dec 13 |
42. Genetics and domestication |
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Daily |
Lecture |
| Dec 14 |
Exam III Tuesday Evening 7:15 till 9:15 - Room 125 Ag Hall (Lectures 28 to 41) |
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Practice Exam |
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| Dec 15 |
43. Overview |
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| Dec 18 |
Final Exam Saturday Evening 7:25 till 9:25 - Rooms Ingraham 14 and B10 (covers the whole course) |
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Instructors |
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Email |
Office |
Office Hour |
Voice |
| John Doebley |
jdoebley@wisc.edu |
5320 Genetics/Biotechnology |
Thursday 9:30-10:30 or by appointment |
265-5803 |
| Allen Laughon |
alaughon@wisc.edu |
4262 Genetics/Biotechnology |
Friday 3:30-4:30 or by appointment |
262-6191 |
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Teaching Assistants |
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Email |
Office Hour |
Where |
| Katie Clowers |
clowers@wisc.edu |
Tue 11:00 or Wed 4:30 |
1421 Genetics/Biotechnology |
| Celeste Eno |
ceno@wisc.edu |
Mon 12:05 or Wed 12:05 |
1421 Genetics/Biotechnology |
| Liz Hines |
ehines@wisc.edu |
Tue 5:30 or Fri 11:00 |
1421 Genetics/Biotechnology |
| Sharolyn Kawakami |
skawakami@wisc.edu |
Tue 3:30 or Fri 8:50 |
1421 Genetics/Biotechnology |
| Virginia Lamb |
vslamb@wisc.edu |
Mon 8:50 or Thu 5:00 |
1421 Genetics/Biotechnology |
| Alison Muir |
amuir@wisc.edu |
Mon 5:00 or Wed 2:25 |
1421 Genetics/Biotechnology |
| Jennifer Pleiman |
pleiman@wisc.edu |
Tue 7:45 or Wed 7:45 |
1421 Genetics/Biotechnology |
| Elise Walck-Shannon |
walck@wisc.edu |
Thu 3:30 or Fri 2:25 |
1421 Genetics/Biotechnology |
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