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Genetics 466 Course Outline - Fall 2008
2:25 MWF 132 Noland Hall

Prof. Sean Carroll
Prof. John Doebley

 

 

 
Date Lecture Topic Readings Suggested Problems    
Part 1. Genes, Chromosomes and Linkage        
Sept 3 1. Mendel and The Study of Inheritance 1:1-28; 2:31-42 2:22, 26, 30, 33, 35, 36, 55, 58 Daily Lecture
Sept 5 2. Cell Cycle, Mitosis and Meiosis 2:42-61 2:4, 8, 9, 13, 14, 17 Daily Lecture
Sept 8 3. Probability for Genetic Events 3:89-97, Handout D1 3:1-3, 14, 17-20, 37 Daily Lecture
Sept 10 4. Probability for Repeated Trials Handout D2 3:35b Daily Lecture
Sept 12 5. Testing Genetic Hypotheses 3:97-99, Handout D3 3:13, 25, 26 Daily Lecture
Sept 15 6. Extensions to Mendelism 6:221-249 6:2, 5-14, 21, 33, 44, 51, 53 Daily Lecture
Sept 17 7. Chromosomes, Sex and Mendel 2:61-75 2:29, 37-38, 42-43, 46-48, 50, 52 Daily Lecture
Sept 19 8. Chromosome Number 16:555-572 16:2, 4, 10, 34-35, 37, 39, 51 Daily Lecture
Sept 22 9. Chromosome Rearrangements 16:572-586 16:15, 19, 23, 24, 28 Daily Lecture
Sept 24 10. Linkage and Mapping I 4:129-144, 155-157, 159-162, Handout D4 4:1-4, 7, 9-10, 12-13, 27, 37, 44, 53 Daily Lecture
Sept 26 11. Linkage and Mapping II 4:154-155, 162-163 4:25-26, 28a, 33-34, 38 Daily Lecture
Sept 29 12. Linkage and Mapping III 4:158-159, Handout D5 4:23, 43 Daily Lecture
Oct 1 13. Model Organisms 1:17-21, 759-773 - Daily Lecture
Oct 2 Exam I Thursday Evening 7:15 till 9:15 - Rms B102 & B239 Van Vleck (Lectures 1 to 13)   (Practice Exam)    
Part 2. Molecular Biology of the Gene        
Oct 3 14. Central Dogma I: DNA 7:265-275 7:1-4, 11, 16; SP 1-2    
Oct. 6 15. Central Dogma II: Replication 7:275-291 7:5-8, 19, 21, 23-24    
Oct. 8 16. Central Dogma III: RNA transcription 8:295-308 8:1-2, 7, 12, 14,18    
Oct 10 17. Translation and Genetic Code I 9:320-333 9:1-3, 6, 9; SP 1-2    
Oct. 13 18. Translation and Genetic Code II 9:333-344 9:5, 17, 24, 27, 28, 32    
Oct. 15 19. Gene Expression I: lac operon 10:351-363 10:1-2, 4, 6; SP 1-2    
Oct. 17 20. Gene Expression II: operators and repressors 10:363-371 10:5, 9, 13, 15    
Oct. 20 21. Gene Expression III: Phage and gene batteries 10:372-379 10:7-8, 16-18    
Oct. 22 22. Eukaryotic gene regulation I 11:385-394 11:1-3    
Oct. 24 23. Eukaryotic gene regulation II 11:394-401, 404-406 11:4-8, 10, 15, 17    
Oct. 27 24. Animal Development I: The toolkit 12:415-423 -    
Oct. 29 25. Animal Development II: The homeobox 12:423-432 12:1-3, 7-9    
Oct 31 26. Animal Development III: Building Animals 12:432-439 12:4, 6, 10-13    
Nov 3 27. Animal Development IV: Building Animals 12:439-449 12:14-16    
Part 3. Evolutionary Genetics        
Nov 4 Exam II Tuesday Evening 7:15 till 9:15 - Rm 125 Ag Hall (Lectures 14 to 26)        
Nov 5 28. Reverend Darwin's Detour Into the Jungle: Chapter 1 TBA    
Nov 7 29. Genomics and the new Genetics 13:453-468 13:1-2, 6, 11, 13, 15    
Nov 10 30. Comparative Genomics and Reverse Genetics 13:468-483 13:16-18, 22, 24    
Nov 12 31. Evolution of Gene Function I: Sickle Cell Safari Into the Jungle: Chapter 8 TBA    
Nov 14 32. Evolution of Gene Function II: In Cold Blood Into the Jungle: Chapter 9 TBA    
Nov 17 33. Morphological Evolution 19:694-699, TBA TBA    
Nov 19 34. Endless Forms Most Beautiful TBA TBA    
Nov 21 35. Hardy-Weinberg & The Gene Pool Concept 17:603-618 17:2-3, 10a, 12 Daily Lecture
Nov 24 36. Inbreeding 17:618-622 17:16, 20 Daily Lecture
Nov 26 37. Genetic Drift 17:631-633, 19:690-693 - Daily Lecture
Dec 1 38. Modeling Natural Selection 17:623-631 17:5-6, 11 Daily Lecture
Dec 3 39. The Inheritance of Complex Traits 18:639-646, 664-671, Handout D6 18:2, 6-7 (data file) Daily Lecture
Dec 5 40. Nature versus Nurture 18:651-659, 671-673, Handout D7 - Daily Lecture
Dec 8 41. Genetics of Plant and Animal Breeding 18:659-664, Handout D8 18:5, 14 Daily Lecture
Dec 9 Exam III Tuesday Evening 7:15 till 9:15 - Rm 125 Ag Hall (Lectures 27 to 41)   (Practice Exam) KEY  
Dec 10 42. Genetics and domestication - - Daily Lecture
Dec 12 43. Overview - - - -
Dec 16 Final Exam Tuesday Afternoon 2:45 till 4:45 - Rm 6210 Social Science (covers the whole course)     KEY  
           

 

 

 
Instructors
  Email Office Office Hour Voice
Sean Carroll sbcarrol@wisc.edu 201A Bock Labs by appointment 262-6191
John Doebley
jdoebley@wisc.edu
5320 Genetics/Biotechnology by appointment 265-5803

 

 
Teaching Assistants
  Email Office Hour Where
Sarah Hanson sahanson3@wisc.edu Tuesday, 1:00-2:00 Zoo Res Bldg, Rm 321
Drew Hasley hasley@wisc.edu Friday, 12:05-12:55 Gen/Biotech, Rm 1421
Sarah Marsh smarsh2@wisc.edu Wednesday, 4:35-5:25 Gen/Biotech, Rm 1421
Laura Shannon lshannon@wisc.edu Monday, 1:20-2:10 Gen/Biotech, Rm 1421

 

 

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  Last updated September 3, 2008